Bupivacaine Hydrochloride & Dextrose is indicated for-
Bupivacaine is an amide-type long-acting anesthetic. Bupivacaine and glucose have a quick onset and a long duration. The duration of analgesia in the T10T12 segment was 23 hours. Bupivacaine hydrochloride can produce moderate muscle relaxation of the lower limbs for 22.5 hours. Blocking of the abdominal muscles makes this solution suitable for abdominal surgery that lasts 45 to 60 minutes.
The doses recommended below should be regarded as a guide for use in the average adult. Spinal anaesthesia for surgery: 2-4 ml (10-20 mg Bupivacaine hydrochloride). The spread of anaesthesia obtained with Bupivacaine depends on several factors including the volume of the solutions and the position if the patients during and following the injection. When injected in the L3-L4 intervertebral space with the patient in the sitting position, 3 ml of Bupivacaine spreads to the T7- T10 spinal segments. With the patient receiving the injection in the horizontal position and then turned supine, the blockade spine spreads to T4-T7 spinal segments. It should be understood that the level of spinal anaesthetic can be unpredictable in a given patient.
Patients receiving antiarrhythmic drugs with local anesthetic activity should use bupivacaine with caution because its toxic effects can be superimposed. Phenothiazine and butyrylbenzene can reduce or reverse the boosting effect of adrenaline.
It is known that patients who are allergic to bupivacaine glucose or any amide local anesthetics should not use bupivacaine glucose. The following conditions do not include the use of spinal anesthesia: severe bleeding, severe hypotension or shock, and arrhythmia, such as complete heart block, severely restricted cardiac output, local infection at the recommended lumbar puncture site, and sepsis.
The adverse reaction characteristics of bupivacaine are similar to other long-acting local anesthetics administered intrathecally. Adverse reactions caused by drugs are difficult to distinguish from the physiological effects of nerve block (such as blood pressure drop, bradycardia, temporary urinary retention), direct (such as neurological trauma) or indirect (such as epidural abscess) events. ) From the needle. Punctures or events related to cerebrospinal fluid leakage (for example, headache after dural puncture).
It is reasonable to assume that bupivacaine has been used in a large number of pregnant women and women of childbearing age. So far, no specific changes in the reproductive process have been reported, page 10. For example, it did not increase the incidence of deformities. It should be noted that patients in late pregnancy should reduce the dose.
At the recommended dose, bupivacaine enters breast milk in a small amount and generally does not affect the baby. When the maternal serum level produced by the epidural use of bupivacaine for vaginal delivery is as high as 0.45 µg/ml, bupivacaine cannot be detected in breast milk within the first 24 hours after delivery (the detection limit is 0.02 µg /ml).
Bupivacaine should be used with caution in the elderly, frail patients and children, patients with epilepsy, respiratory failure, impaired cardiac conduction, bradycardia, severe shock; porphyria; myasthenia gravis. Myocardial depression may be more severe and resistant to treatment.
Regional anesthesia
Store in a cool and dry place. Protect from light.
Bupivacaine Hydrochloride + Dextrose
Anespine
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