Arixon-IV 250Injection

Indications of Arixon IV 250

Arixon is indicated for the treatment of the following major infections when caused by susceptible organisms: Renal and urinary tract infections, Lower respiratory tract infections, particularly pneumonia, Gonococcal infections, Skin and soft tissue, bone and joint infections, Bacterial meningitis, Serious bacterial infections e.g. septicemia, ENT infections, Infections in cancer patients, Prevention of postoperative infection, Perioperative prophylaxis of infections associated with surgery, Typhoid fever.

Pharmaceutical Name of Arixon IV 250

Beximco Pharmaceuticals Ltd.

Pharmacology

Arixon (Ceftriaxone) is a third generation broad spectrum parenteral cephalosporin antibiotic. Arixon interferes with the synthesis of bacterial cell wall by inhibiting transpeptidase enzyme. As a result the bacterial cell wall is weakened, the cell swells and then ruptures.

Dosage & Administration of Arixon IV 250

Arixon (ceftriaxone) can be administered either intravenously or intramuscularly. When reconstituted for intramuscular or intravenous injection, the white to yellowish-orange crystalline powder gives a pale yellow to amber solution. Adults: The usual adult daily dose is 1-2 g once daily, (or twice daily in equally divided doses) depending on the type and severity of infection. The daily dose may be increased, but should not exceed 4 g. For preoperative use (surgical prophylaxis), a single dose of 1 gm administered intravenously 0.5-2 hours before surgery is recommended. In elderly patients, the dosages do not require modification provided that renal and hepatic functions are satisfactory. In patients with impaired renal function, there is no need to reduce the dosage of Arixonprovided liver function is intact. In patients with liver damage,
there is no need for the dosage to be reduced provided renal function is intact. Gonorrhea: For the treatment of gonorrhea (penicillinase producing and non-penicillinase producing strains), a single intramuscular dose of 250 mg is recommended. Children under 12 years: The recommended total daily dose is 50 to 75 mg/kg once daily (or twice daily in equally divided doses). In severe infections, up to 80 mg/kg body weight daily may be given. The total daily dose should not exceed 2 gm. In the treatment of meningitis, the initial dose of 100 mg/kg body weight (not to exceed 4 gm daily) once daily (or twice daily in equally divided doses), is recommended. As soon as the causative organism has been identified and its sensitivity, the doses can be reduced accordingly. The usual duration of therapy in meningitis is 7 to 14 days.

Interaction of Arixon IV 250

Potentially hazardous interactions: No impairment of renal function or increased nephrotoxicity has been observed in man after simultaneous administration of ceftriaxone with diuretics, or with aminoglycosides. A possible disulfiram-like reaction may occur with alcohol. Other significant interactions: Arixon doesn't interfere with the protein binding of bilirubin. Simultaneous administration of probenecid doesn't alter the elimination of ceftriaxone. Potentially useful interactions: Experimentally, in vivo, ceftriaxone has been shown to enhance bacterial killing by human neutrophils. 

Contraindications

Patients with a history of allergies to cephalosporin antibiotics should not use ceftriaxone.

Side Effects of Arixon IV 250

Arixon is generally well tolerated. A few side-effects such as 1. Gastrointestinal effects include diarrhea, nausea and vomiting, stomatitis and glossitis 2. Cutaneous reactions include rash, pruritus, urticaria, edema & erythema multiforme 3. Hematological reactions include eosinophilia, thrombocytosis, leukopenia, and neutropenia 4. Hepatic reactions include elevations of SGOT or SGPT, bilirubinemia 5. CNS reactions include headache, hyperactivity, nervousness, sleep disturbances, confusion, hypertonia, and dizziness were reported. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Pregnancy & Lactation

Arixon has not been associated with adverse effects on fetal development in laboratory animals, but its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Because ceftriaxone is distributed into milk, the drug should be used with caution in nursing women.

Precautions & Warnings

Like other cephalosporins, even if the patient has a complete medical history, anaphylactic shock cannot be ruled out. Anaphylactic shock requires immediate countermeasures, such as intravenous epinephrine and then glucocorticoids. In rare cases, ultrasound of the gallbladder detects shadows suggestive of deposits. This condition is reversible when ceftriaxone treatment is suspended or completed. Even if these findings are related to pain, conservative and non-surgical treatment is recommended. During long-term treatment, the blood picture should be checked regularly.

Therapeutic Class

Third Generation Cephalosporins

Storage Conditions

Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately. Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).

Generic of Arixon IV 250

Ceftriaxone Sodium