Clindacin 300Capsule

Indications of Clindacin 300 Capsule

When caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as Streptococci, Staphylococci, and Pneumococci, clindamycin has been shown to be effective in the treatment of the following infections: upper respiratory infections, lower respiratory infections, skin and soft tissue infections, bone and joint infections, pelvic infections, and intra-abdominal infections. When used with quinine or amodiaquine, as an alternate medication for the treatment of multi-drug resistant Plasmodium falciporum infection.

Pharmacology of Clindacin 300 Capsule

In oral and parenteral formulations, clindamycin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, as well as susceptible staphylococci, streptococci, and pneumococci.14,15 Used topically, it is indicated for the treatment of acne vulgaris12,18,16 and is available in combination with benzoyl peroxide10 or tretinoin11 for this purpose. Clindamycin is also indicated as a vaginal cream13 or suppository17 for the treatment of bacterial vaginosis in non-pregnant females.

Clindamycin is used for antimicrobial prophylaxis against Viridans group streptococcal infections in susceptible patients undergoing oral, dental, or upper respiratory surgery, and may be used for prophylaxis against bacterial endocarditis in penicillin-allergic patients at high risk of these infections.20

Dosage & Administration of Clindacin 300 Capsule

Dosage of Clindamycin Capsule:

• Serious Infections: 150 mg-300 mg every six hours.
• More severe infections: 300 mg-450 mg every six hours.

To avoid the possibility of oesophageal irritation, Clindacin capsules should be taken with a full glass of water.

Several researches has found that Clindamycin 300 mg capsule provides plasma concentration over MIC₉₀ for more than 12 hours. This finding supports the twice-daily dosing of Clindacin 300 mg capsule, particularly in SSTIs & RTIs. However, in case of bone & joint infections, diabetic foot infections dose of Clindamycin should be 300 mg capsule 3-4 times daily.

Dosage of Clindamycin Powder for oral solution:

• Serious infections: 8-12 mg/kg/day divided into 3 or 4 equal doses.
• Severe infections: 13-16 mg/kg/day divided into 3 or 4 equal doses.
• More severe infections: 17-25 mg/kg/day divided into 3 or 4 equal doses.

In pediatric patients weighing 10 kg or less, 1/2 teaspoon (37.5 mg) three times a day should be considered the minimum recommended dose.

Dosage of Clindamycin IV/IM Injection:
Adults-

• Serious infections due to aerobic gram-positive cocci and the more susceptible anaerobes: 600-1200 mg/day in 2- 4 equal doses.
• More severe infections: 1200-2700 mg/day in 2-4 equal doses.
• For more serious infections: these doses may have to be increased. In life-threatening situations due to either aerobes or anaerobes, these doses may be increased.
• Doses of as much as 4800 mg daily have been given intravenously to adults. Single intramuscular injections of greater than 600 mg are not recommended.

Neonates (less than 1 month): 15 to 20 mg/kg/day in 3 to 4 equal doses. The lower effective dosage may be adequate for small prematures.

Pediatric patients (1 month of age to 16 years):

• 20 to 40 mg/kg/day in 3 or 4 equal doses. The higher doses would be used for more severe infections.
• Parenteral therapy may be changed to Capsules (clindamycin hydrochloride) when the condition warrants and at the discretion of the physician.
• In cases of (3-hemolytic streptococcal infections, treatment should be continued for at least 10 days.

Interaction of Clindacin 300 Capsule

Clindamycin boosts the effectiveness of other neuromuscular blockers. As a result, it should be taken with caution in patients who are taking such medications. Clindamycin and erythromycin have been shown to be antagonistic in vitro. These two medicines should not be used at the same time because of the potential for clinical complications.

Contraindications

Clindamycin is not recommended for patients who have previously tested positive for clindamycin or any of its components.

Side Effects of Clindacin 300 Capsule

Abdominal discomfort, oesophagitis and oesophagial ulcer, nausea, vomiting, and diarrhoea, pruritus, skin rashes, and urticaria have all been described as side effects of clindamycin usage.

Pregnancy & Lactation

Pregnancy Classification B. Clindamycin is a drug that can pass the placenta in humans. Amniotic fluid concentrations were around 30% of maternal amounts after several dosages. Clindamycin should only be taken during pregnancy if absolutely necessary. It has been reported that clindamycin can be found in breast milk. As a result, unless absolutely necessary, it is not suggested for breastfeeding moms.

Precautions & Warnings

Clindamycin should be used with care in people who have had gastrointestinal problems, especially colitis.

Therapeutic Class

Macrolides

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Pharmaceutical Name of Clindacin 300 Capsule

Incepta Pharmaceuticals Ltd

Generic of Clindacin 300 Capsule