Cox B-100Capsule

Indications of Cox B 100mg Capsule

Cox B 100mg Capsule is indicated- For the help of the signs and side effects of osteoarthritis. For the help of the signs and side effects of rheumatoid arthritis. For the relapse and avoidance of colorectal adenomatous polyps in patients with familial adenomatous polyposis (FAP).

Pharmacology of Cox B 100mg Capsule

Celecoxib may be a particular cyclooxygenase-2 (COX-2) inhibitor, nonsteroidal anti-inflammatory sedate (NSAID). It shows anti-inflammatory, pain-relieving, and antipyretic properties. The component of activity of Celecoxib is accepted to be due to the restraint of prostaglandin amalgamation, by means of the hindrance of cyclooxygenase-2 (COX-2) chemical. At restorative concentration, Celecoxib does not repress cyclooxygenase-1 (COX-1) isoenzyme.

Cox B 100mg Capsule Administration & Dosage

Osteoarthritis: The recommended oral dose is 200 mg per day administered as a single dose or as 100 mg twice daily.

Rheumatoid arthritis: The recommended oral dose is 100 to 200 mg twice daily.

Familial adenomatous polyposis (FAP): Usual medical care for FAP patients should be continued while on Celecoxib. To reduce the number of adenomatous colorectal polyps in patients with FAP, the recommended oral dose is 400 mg (2x200 mg capsules) twice daily to be taken with food.

Interaction

Pro inhibitors: Reports propose that NSAIDs may decrease the antihypertensive impact of Expert inhibitors. This interaction ought to be given into thought in patients taking Celecoxib concomitantly with Pro inhibitors. Frusemide: NSAIDs can decrease the natriuretic impact of Frusemide and thiazides in a few patients. Aspirin: Celecoxib can be utilized with moo measurements Ibuprofen. In any case, concomitant organization of Headache medicine with Celecoxib may result in an expanded rate of gastrointestinal ulceration or comparative complications, compared to the utilize of Celecoxib alone.

Fluconazole: Concomitant organization of Fluconazole at 200 mg qid come about in a two overlay increment in Celecoxib plasma concentration. Celecoxib ought to be presented at the most reduced suggested dosage in patients accepting Fluconazole.

Lithium: Patients on Lithium treatment ought to be closely observed when Celecoxib is presented or withdrawn. Warfarin: Caution ought to be utilized when regulating Celecoxib with Warfarin since these patients are at expanded hazard of dying complications. Co-administration of Celecoxib with aluminum and magnesium-containing stomach settling agent ought to be maintained a strategic distance from, since they may diminish the sum of Celecoxib that the body retains.

Contraindications

Celecoxib is contraindicated in patients with known touchiness to Celecoxib. It ought to not be given to patients who have illustrated unfavorably susceptible sort responses to Sulphonamides (Celecoxib contains a sulphonamide side chain). Celecoxib ought to not be given to patients who have illustrated asthma, urticaria, or unfavorably susceptible sort responses after taking Ibuprofen or other NSAIDs. Extreme, seldom lethal, anaphylactic-like responses to NSAIDs have been detailed in such patients.

Cox B 100mg Capsule Side Effect

Antagonistic occasions happening in ≥2% of patients at prescribed measurements - Stomach torment 4.1%, loose bowels 5.6%, dyspepsia 8.8%, tooting 2.2%, queasiness 3.5%, back torment 2.8%, fringe oedema 2.1%, inadvertent damage 2.9%, tipsiness 2.0%, cerebral pain 15.8%, a sleeping disorder 2.3%, pharyngitis 2.3%, rhinitis 2.0%, sinusitis 5.0%, upper respiratory tract contaminations 8.1%, hasty 2.2%.

The taking after antagonistic occasions happened in 0.1-1.9% of patients-

General: Hypersensitivity irritated, unfavorably susceptible response, asthenia, chest torment, edema summed up, confront edema, weariness, fever, hot flushes, flu-like indications, torment, fringe pain.

Gastrointestinal: Obstruction, diverticulitis, dysphagia, oesophagitis, gastritis, gastroenteritis, gastro-oesophageal reflux illness, hemorrhoids, hiatal hernia, melaena, dry mouth, stomatitis, tenesmus, tooth clutter, vomiting.

Cardiovascular: Disturbed hypertension, angina pectoris, coronary supply route infection, myocardial infarction.

Nervous framework: Leg issues, hypertonia, hypoesthesia, Resistance instrument clutters: Herpes simplex, herpes zoster, bacterial contamination, parasitic contamination, contamination of delicate tissue, viral disease, moniliasis, moniliasis genital, otitis media.

Hearing and vestibular: Deafness, ear variation from the norm, ear infection, tinnitus.

Heart rate and cadence: Palpitation, tachycardia.

Respiratory: Bronchitis, bronchospasm, bronchospasm irritated, hacking, dyspnoea, laryngitis, pneumonia.

Liver and biliary framework: Peptic work irregular, expanded AST and ALT.

Musculoskeletal: Arthralgia, arthrosis, coincidental break, myalgia, neck solidness, synovitis, tendinitis.

Urinary framework: Albuminuria, cystitis, dysuria, haematuria, micturition recurrence, renal calculus, urinary incontinence, urinary tract infection.

Metabolic and wholesome: Blood urea nitrogen (BUN), CPK, creatinine, soluble phosphatase, are expanded. Hypercholesterolaemia, hyperglycemia, hypokalaemia. Bodyweight is additionally increased.

Psychiatric: Anorexia, uneasiness, expanded craving, misery

Pregnancy & Lactation

Celecoxib ought to be utilized amid pregnancy as it were in the event that the potential advantage legitimizes the potential chance to a baby. But in late pregnancy, Celecoxib ought to be dodged since it may cause untimely closure of ductus arteriosus. It isn't known whether Celecoxib is excreted in the human brain. Since numerous drugs are excreted in human milk as a result of the potential for genuine antagonistic responses in nursing newborn children from Celecoxib, a choice should be made whether to cease nursing or to suspend the sedate, taking into consideration the significance of the sedate to the mother.

Precautions & Warnings

Celecoxib, at measurements up to 200 mg offered, can be managed without respect to the timing of supper. Higher measurements (400 mg offered) ought to be managed with nourishment.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

Pharmaceutical Name