Duofilm 15Solution

Generic

Salicylic Acid + Lactic Acid

Indications

This is a topical solution used to treat warts, corns, and calluses.

Patients' Information

• Warts: A wart is a viral infection of the skin's superficial layers. Incubation times range from a few weeks to several months. Warts can spread to injured skin by direct contact with a wart.
• Corns are tiny, hardened areas of skin that frequently seem yellow in comparison to the surrounding skin. It is usually spherical or cone-shaped and points downward into the skin. Corns are most commonly found on the feet, but can also appear on the hands, and are generated by persistent or repetitive friction or pressure.
• Calluses are rough, thickened patches of skin that cover a large region. Calluses are similar to corns in that they are created by persistent or repetitive friction or pressure, but unlike corns, they are flat and have typical skin lines.

Pharmacology

Salicylic acid is a popular and efficient keratolytic; it causes desquamation and loss of the epithelium by dissolving the Stratum Corneum's intercellular cement. Lactic acid influences the keratinisation process, decreasing hyperkeratosis, and is also caustic, causing hyperkeratotic tissue to be destroyed. Collodion is created by combining cellulose with ethanol and ether in a base. It enables simple and accurate product application and dries to leave a layer that hydrates the tissue and improves active ingredient penetration.

Dosage & Administration

Unscrew bottle cap and with the help of brush applicator, apply to the affected areas. ‘Before starting to use this topical solution, unscrew the fitted cap, discard it. Carefully remove the plug away from your body to avoid splashing into eyes/ face and discard it, replace with the brush applicator cap provided in

the sealed polybag given in the carton. This topical solution should be applied to the affected areas once daily, according to the following instructions:

• Soak affected site in hot water for five minutes.
• Rub surface carefully with pumice stone or emeryboard to remove any hard skin. Dry with your own towel.
• Apply this topical solution using the brush applicator supplied, taking care to avoid contact with normal skin.
• Allow to dry thoroughly and cover with plaster if lesion is large or on the foot to help penetration of active ingredients.
• Continue treatment once daily until the lesion is completely cleared and the ridge lines of the skin have been restored or when the corn can be removed.
• The usual treatment period is 6 to 12 weeks.

Interaction

There are no known or well-documented medication interactions.

Contraindications

Not to be used in high quantities or on significant regions of the body for an extended period of time. Diabetes or impaired peripheral circulation. Avoid contact with damaged skin, the mouth, the eyes, the mucous membranes, and the anogenital area.

Side Effects

Skin stinging, burning, or irritation Itching, as well as extended usage over a broad skin region, may result in salicylate poisoning, ringing in the ears (tinnitus), diarrhoea, and vomiting.

Pregnancy & Lactation

Not Classified as a Pregnancy Category. The FDA has yet to assign the medication to a specific pregnancy category.

Precautions & Warnings

Because this preparation is designed for the controlled corrosion of keratin, it should only be applied to the afflicted region. Use with caution on the face and anogenital areas, as well as if you are diabetic or have impaired circulation. Use with caution on moles, birthmarks, and other odd skin growths. Do not treat large regions of warts at once, and do not use on babies or very young children unless under physician supervision. Only for External Use.

Therapeutic Class

Combinations of preparations

Storage Conditions

Because of their high flammability, Salicylic Acid and Lactic Acid should be kept in a cool area not exceeding 25°C. Keep a safe distance from open flames. Keep out of children's reach. Because this topical solution is flammable, be sure to firmly seal the bottle after each use.

Pharmaceutical Name

Glaxo Smithkline Bangladesh Limited