Eromycin 250Tablet

Indications of Eromycin 250 Tablet

Erythromycin is highly effective in the treatment of a wide variety of clinical infections.

• Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, laryngitis, Sinusitis. Secondary infections in colds and influenza.
• Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis.
• Ear infections: Otitis media, otitis externa, mastoiditis.
• Eye infections: Blepharitis, established trachoma.
• Skin and Soft tissue infections: Boils and carbuncles, impetigo, abscesses, pustular acne, paromychia, cellulitis, erysipelas.
• Gastrointestinal tract infections: Cholecystitis, staphylococcal enterocolitis.
• Prophylaxis: Pre and post-operative, trauma, burns, rheumatic fever.
• Other infections: Osteomyelitis, diptheria, scarlet fever, whooping cough.

Pharmacology of Eromycin 250 Tablet

Erythromycin restrains microsomal protein blend in vulnerable living beings by restraining the translocation prepare. Particular authoritative to the 50S subunit or 70S ribosome happens in these life forms but there's no official to the steady 80S mammalian ribosome. Erythromycin is dynamic against numerous Grampositive microscopic organisms, a few Gram-negative microbes and against mycoplasmas and chlamydia. Absorption: Erythromycin base is annihilated by corrosive and is therefore managed within the frame of steady ester. The rates of retention of the base and esters are decreased by the presence of nourishment. The stearate is hydrolyzed within the digestive system and the free erythromycin ingested.

Administration & Dosage of Eromycin 250 Tablet

Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections. This may be increased upto 4 gm. or more daily in severe cases.

Elderly: No special dosage recommendation. Erythromycin may be administered if desired, three times daily or twice daily by giving one-third or half of the total daily requirement 8 hourly or 12 hourly respectively.

Children aged 2 to 8 years: 250 mg. every six hours or 30-50 mg/kg body weight per day divided into four equal dosage.

Infants and Children upto 2 years: 500 mg. in divided doses or 30-50 mg/kg body weight in divided doses.

Interaction of Eromycin 250 Tablet

Recent data from studies of erythromycin reveals that its use in patients who are receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity. In such cases this dose of theophylline should be reduced.

Contraindications

Known hypersensitivity to Erythromycin.

Side Effects of Eromycin 250 Tablet

Allergic reactions are rare and mild although anaphylaxis has occurred. Occasionally there is abdominal discomfort after oral administration, sometimes with nausea and vomiting. This discomfort usually subsides after a few days without it being necessary to reduce the dosage.

Pregnancy & Lactation

Clinical and Laboratory studies have been shown no evidence in human of teratogenicity or toxicity. However, caution should be exercised when prescribing this drug to pregnant patients and lactating mothers since erythromycin crosses the placental barrier and is excreted in breast milk.

Precautions & Warnings

Erythromycin should be given with care in patients with impaired hepatic function, as erythromycin is excreted principally in the bile.

Therapeutic Class

Anti-diarrhoeal Antimicrobial drugs, Macrolides

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

Pharmaceutical Name of Eromycin 250 Tablet