Generics:Sodium Fusidate (Topical) 2%
Sodium Fusidate
Skin infections caused by Staphylococci, Streptococci, Corynebacterium minutissimum, and other Fusidate sensitive organisms are treated with Sodium Fusidate Ointment. Impetigo, boils, abscesses, varicose ulcers, skin grafts, hidradenitis, infected wounds, sycosis barbae, paronychia, folliculitis, carbuncles, and erythrasma are the most common indications.
Clostridium is an antibiotic derived from Fusidium coccineum, which has strong activity against various gram-positive bacteria. Staphylococcus, including strains resistant to penicillin or other antibiotics, are particularly sensitive to sodium fusidate. The therapeutic efficacy of topical sodium fusidate is partly due to the significant antibacterial activity of sodium fusidate against microorganisms that cause skin infections, and partly due to the unique ability of this antibiotic to penetrate intact skin.
Fusidic acid is an antibacterial agent, which can be used as an inhibitor of protein synthesis in microorganisms. It interferes with the translocation step by stabilizing the G complex of ribosomal guanosine phosphate elongation factor. This prevents the aminoacyl tRNA from binding to the ribosome and then stops the transfer of additional amino acids to the growing peptide.
Sodium Fusidate Ointment or cream is applied to the affected areas 2 to 3 times daily, generally for a period of 7 days. It can be used with or without a covering dressing. Caution should be observed when applying Sodium Fusidate Ointment near the eye region as this preparation may cause irritation if it gets into the eye. No special dosage modifications or special precautions are required for children.
Known hypersensitivity to Sodium Fusidate, severe hepatic failure.
Sodium Fusidate Ointment is remarkably well tolerated, and there is an extremely low frequency of hypersensitivity reactions.
Caution should be observed when applying Sodium Fusidate ointment in the eye region as this preparation may cause irritation upon contact with the eye.
Topical Antibiotic preparations
Eskayef Pharmaceuticals Ltd.
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