FlixonaseNasal Spray

Generic

Fluticasone Propionate

Indications

Fluticasone Propionate is prescribed for the following conditions:

• Seasonal allergic rhinitis, including hay fever and persistent rhinitis, prevention and therapy.
• It has strong anti-inflammatory action on the nasal mucosa but little systemic activity.

Pharmacology

Fluticasone propionate has anti-inflammatory and vasoconstrictor properties after topical application to the nasal mucosa. The precise mechanism of these actions is unknown, but it may involve a decrease in the number of mediator cells (basophils, leukocytes, and mast cells) at the epithelial level, the number of eosinophils, sensory nerve sensitivity to mechanical stimuli, secretory response to cholinergic receptor stimulation, and fibroblast activity. Other methods may include capillary dilatation and permeability inhibition, lysosomal membrane stability, and consequent suppression of proteolytic enzyme release.

Dosage

Adults & children over 12 years: 2 sprays in each nostril once a day preferably in the morning. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.

Children under 12 years (4-11 years): 1 spray in each nostril once a day. The maximum total daily dosage should not exceed 4 sprays. For perennial rhinitis in children, there are insufficient clinical data to recommend its use.

Children below 4 years: The safety and effectiveness of Fluticasone Propionate nasal spray in children below 4 years of age have not been established.

Patients should use Fluticasone Propionate Nasal Spray at regular intervals as directed since its effectiveness depends on its regular use. Or as directed by the physician.

 Administration

How to use the Nasal Spray-

• Shake the bottle gently and remove the dust cover.
• Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine moist comes out from the container.
• Gently blow the nose to clear the nostrils.
• Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white-collar of nasal applicator firmly down once to release a spray.
• Breathe out through your mouth.
• Repeat the above steps in the same/ other nostril for consecutive doses.

Cleaning: The nasal spray should be cleaned at least once a week. The procedures are as follows-

• Remove the dust cover.
• Gently pull off the nasal applicator.
• Wash the applicator and dust cover in warm water.
• Shake off the excess water and leave to dry in a normal place. Avoid to apply additional heat.
• Gently push the applicator back on the top of the bottle and re-fix the dust cover.

Contraindications

Fluticasone Propionate nasal spray is not recommended for people who are allergic to any of its components.

Side Effects

Fluticasone Propionate nasal spray is less absorbed into the body, resulting in less adverse effects. Nasal spray may cause dryness of the nose and throat, unpleasant taste and odor, and an increase in the frequency of nosebleeds.

Pregnancy & Lactation

In pregnant women, there are no appropriate and well-controlled trials. Fluticasone Propionate should only be taken during pregnancy if the possible benefit outweighs the danger to the baby. Fluticasone Propionate is not known to be excreted in human breast milk. Because other corticosteroids are excreted in human milk, a breastfeeding woman should take caution when using Fluticasone Propionate nasal spray.

Precautions & Warnings

Following intranasal use of corticosteroids, including Fluticasone Propionate, rare cases of wheezing, nasal septum perforation, cataracts, glaucoma, and elevated intraocular pressure have been documented. Although the systemic effects of Fluticasone Propionate nasal spray have been limited, With higher dosages, the risk of toxicity rises. As a result, higher-than-recommended Fluticasone Propionate nasal spray dosages should be avoided.

Therapeutic Class

Nasal Steroid Preparations, Fluocinolone & Combined Preparations

Storage Conditions

Keep all medications out of the reach of youngsters. Store in a cold, dry, and light-protected location.

Pharmaceutical Name

Glaxo Smithkline Bangladesh Limited