Klabid 70 mlPowder for Suspension

Indications of Klabid 70 ml Powder for Suspension

• Streptococcal pharyngitis Sinusitis Clarithromycin is used to treat Streptococcal pharyngitis.
• Infectious bronchitis exacerbations Community-acquired pneumonia
• Pneumonia with a twist
• Infection of the skin and soft tissues
• Adjunct in the treatment of duodenal ulcers caused by H.pylori elimination.

Pharmacology of Klabid 70 ml Powder for Suspension

Clarithromycin works by binding to the donor site on the 50S subunit of the bacterial ribosome and limiting translocation to that site, which inhibits microsomal protein production in sensitive species. Most Gram-positive bacteria including Chlamydia, as well as some Gram-negative bacteria and Mycoplasmas, are susceptible to clarithromycin. In vitro, Clarithromycin has activity comparable to or greater than Erythromycin against most Gram-positive bacteria. Clarithromycin is better tolerated since it is more acid-stable than Erythromycin. Clarithromycin is twice as effective against H. influenzae as Erythromycin. Clarithromycin is resistant to the majority of Gram-negative bacteria.

Dosage & Administration of Klabid 70 ml Powder for Suspension

Adults:

Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days.

Acute maxillary sinusitis 500 mg every 12 hours for 14 days.

Chronic bronchitis 250-500 mg every 12 hours for 7-14 days.

Pneumonia 250 mg every 12 hours for 7-14 days.

Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days.

Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days.

Children:

Bodyweight under 8 kg: 7.5 mg/kg twice daily.

Bodyweight of 8-11 kg (1-2 years): 2.5 ml (Half teaspoonful) twice daily.

Bodyweight of 12-19 kg (3-6 years): 5 ml (One teaspoonful) twice daily.

Bodyweight of 20-29 kg (7-9 years): 7.5 ml (One & half teaspoonfuls) twice daily.

Bodyweight of 30-40 kg (10-12 years): 10 ml (Two teaspoonfuls) twice daily.

Clarithromycin may be given with or without meals.

Interactions of Klabid 70 ml Powder for Suspension

Clarithromycin and Theophylline: Taking Clarithromycin and Theophylline at the same time may cause a rise in serum Theophylline levels. Terfenadine: Clarithromycin may affect Terfenadine metabolism.

Contraindications

Clarithromycin, Erythromycin, or any of the macrolide antibiotics cause hypersensitivity. Patients with pre-existing cardiac problems or electrolyte imbalances who are receiving Terfenadine.

Side Effects of Klabid 70 ml Powder for Suspension

Clarithromycin is well tolerated by most people. Nausea, vomiting, diarrhoea, and abdominal pain are some of the side effects. There have also been reports of stomatitis and glossitis. Headaches and allergic reactions ranging from urticaria and moderate skin rashes to anaphylaxis are among the other side effects. It's possible that you'll develop a taste aversion. Anxiety, dizziness, sleeplessness, and delusion have all been reported as temporary central nervous system side effects.

Pregnancy

In proper doses, the medication can be utilized in newborns and children. Infants should not be fed breast milk from mothers who are on Clarithromycin until their treatment is finished. Clarithromycin is not suggested because there is currently insufficient experience with the treatment of pregnant individuals.

Precautions

The liver and kidneys are the main excretion organs for clarithromycin. Patients with compromised hepatic and renal function should be given this antibiotic with caution. The usage of Clarithromycin for an extended period of time or on a regular basis can lead to an overgrowth of non-susceptible bacteria or fungi. If a superinfection develops, Clarithromycin should be stopped and appropriate treatment started.

Therapeutic Class

Macrolides

Storage Conditions

Store in a cool and dry place, protected from light & moisture. The reconstituted suspension must be used within 7 days if kept at room temperature and within 14 days when stored in a refrigerator. Keep out of reach of children.

Pharmaceutical Name of Klabid 70 ml Powder for Suspension

UniMed UniHealth Pharmaceuticals Ltd

Generic of Klabid 70 ml Powder for Suspension

Clarithromycin