LaxylTablet

Indications of Laxyl Tablet

• Emotional disturbance: Acute tension and anxiety states, difficulties in interpersonal contact. agitation, insomnia, anxious and agitated depressive reactions.
• Functional disturbance in the cardiovascular and respiratory systems: Pseudoangina pectoris, precordial anxiet, tachycardia, emotiogenic hypertension, dyspnea and hyperventilation.
• ln the gastrointestinal system: lrritable bowel syndrome, epigastric pain, spasm, bloting diarrhoea, etc.
• ln the genitourinary system: Frequency, irritable bladder and dysmenorrheal
• Psychosomatic disorders: Psychogenic headache, psychogenic dermatosis, asthma, gastric and duodenal ulcer, ulcerative colitis, emotional reactions to chronic oraganic disease, adjuvant to psychotherapy in psychoneurosis..

Pharmacology of Laxyl Tablet

Laxyl', Bromazepam, is rapidly absorbed from the gastro-intestinal tract. Peak plasma concentrations are usually reached within two hours or oral administration of bromazepam. Steady state plasma concentrations are reached in around fve to nine days. Bromazepam is metabolized in liver, Quantitatively, two metabolites predominate: 3' hydroxy - bromazepam and"2 - (2 - arnino - 5 - bromo - 3 hydroxybenzoyl) pyridine. Metabolites of Laxyl' {Bromazepam) do not contribute signifrcantly to the effects ofthe drug.

Dosage & Administration of Laxyl Tablet

The optimum dosage and frequency of administration or Bromazepam should be based on the individual patient, the severity of symptoms and previous psychotropic drug history. The usual dosage in general practice is from 3 mg to 1 8 mg daily in divided doses. ln exceptional circumstances, in hospitalised patients, up to the maximum daily dosage of60 mg, in divlded doses, may be given. Use in elderly: Elderly patients are more sensitive to the actions of Bromazepam. Doses should not exceed half of those normally recommended. The lowest dose which can control symptoms should be used. Treatment should not be continued at the full dose beyond four weeks. Long-term chronic use is not recommended treatment should always be tapered off gradually. Patients who have taken benzodiazepines for a prolonged time may require a longer period during which doses are reduced.5pecialist help may be appropriate. Use in children: Bromazepam is not recommended for paediatric use. Bromazepam tablets are for oral administration.

Interaction of Laxyl Tablet

Bromazepam's sedative effects may be increased when coupled with other centrally active medications. Antidepressants, hypnotics, opioids, antipsychotics, sedatives, antiepileptic medicines, sedative antihistamines, and anesthetics are examples of these medications. Cimetidine may extend bromazepam's elimination half-life when taken together. Bromazepam should not be used with alcohol because the sedative effect of bromazepam may be amplified by the alcohol.

Contraindications

Patients with a known hypersensitivity to bromazepam, severe respiratory insufficiency, severe hepatic insufficiency, or sleep apnea syndrome should not use bromazepam.

Side Effects of Laxyl Tablet

Tiredness, sleepiness, muscular weakness, numbed muscle, decreased alertness, confusion, headache, ataxia, and other common side effects include fatigue, drowsiness, muscle weakness, numbed muscle, reduced alertness, confusion, headache, ataxia, and so on. These side effects are most common at the start of therapy and generally go away after a while. Anterograde amnesia may develop when therapeutic dosages are used.

Pregnancy & Lactation

There is nJevidence as to drug safety in human pregnancy, nor is there evidence from animal workthat it isfree from hazard. Do not use during pregnancy, especially during the first and last trimesters, unless there are compelling reasons The admiiistration of high doses or prolonged administration of low doses of benzodiazepines in the last trimester of pregnancy has been reported to produce itregularities in the foetal heart rate, and hypotonia, poor sucking line-hypothermia intieneonate.Benzodiazepineshavebeandetectedinbreastmilk lfpossible'the use of Bromazepam should be avoided during lacation

Precautions & Warnings

The usage of benzodiazepines and benzodiazepine-like substances may result in physical and psychological dependency on these drugs. This dependency is dosage and treatment length dependent; it is also more prevalent in susceptible patients with a history of alcoholism. Once physical dependency has established, discontinuing therapy will result in withdrawal symptoms. Headache, muscular discomfort, severe anxiety, tension, disorientation, and irritability are some of the symptoms. Because the danger of withdrawal and rebound symptoms increases with sudden termination of therapy, it is suggested that the dosage be gradually reduced. Bromazepam is not indicated as a first-line therapy for insomnia induced by psychotic disease. Driving a car or using machinery should be done with caution.

Therapeutic Class

Sedatives including benzodiazepines

Storage Conditions

Store ielow 30" C. Protected from light & moisture' Keep all the medicines out of the reach of children.

Pharmaceutical Name of Laxyl Tablet

Square Pharmaceuticals Ltd

Generic of Laxyl Tablet

Bromazepam