Lit-15Tablet

Generic

Pioglitazone

Indications

Pioglitazone is suitable for adjunctive therapy to diet and exercise to improve blood sugar control in patients with type 2 diabetes (NIDDM). Pioglitazone is suitable for single drug therapy, and is also suitable for combined use with sulfonylureas, metformin, or insulin, when diet and exercise plus a single drug cannot lead to adequate blood sugar control.

Pharmacology

Pioglitazone is a preparation of pioglitazone, which is a member of the latter class of oral hypoglycemic drugs called thiazolidinediones. Its mechanism of action depends on the presence of insulin. Pioglitazone reduces peripheral and hepatic insulin resistance, which increases insulin-dependent glucose processing and decreases hepatic glucose production. It also improves abnormal lipid metabolism by activating peroxisome proliferator activated receptor gamma (PPAR gamma).

Dosage & Administration

Pioglitazone can be taken once a day without having to consider meals. The management of hypoglycemic therapy should be individualized. For patients who cannot be adequately controlled by diet and exercise alone, pioglitazone monotherapy can be started at a dose of 15 mg or 30 mg once daily. For patients with insufficient response to the initial dose of pioglitazone, the dose can be increased to 45 mg once daily. For patients who do not respond well to single agent therapy, combination therapy should be considered.

The maximum recommended daily dose of pioglitazone should not exceed 45 mg, because doses exceeding 45 mg have not been studied in placebo-controlled clinical studies. In addition, there have been no placebo-controlled clinical studies of more than 30 mg once a day combination therapy.

Interaction

Administration of thiazolidinediones and oral contraceptives containing ethinyl estradiol and norethindrone can reduce plasma concentrations of the two hormones by approximately 30%, which can lead to contraceptive failure.

Contraindications

Pioglitazone is contraindicated in patients known to be allergic to any of its ingredients.

Side-Effects

In placebo-controlled clinical trials, pioglitazone monotherapy doses were 7.5 mg, 15 mg, 30 mg, or 45 mg once daily. The overall incidence and type of adverse reactions reported were upper respiratory tract infection (13.2%), headache (9.1%). , sinusitis (6.3%), myalgia (5.4%), dental disease (5.3%) and pharyngitis (5.1%).

Pregnancy & Lactation

Pregnancy: There are no adequate and well-controlled studies of pregnant women. Pioglitazone should be used during pregnancy only if the potential benefit proves a potential risk to the fetus.

Precautions & Warnings

Pioglitazone only exerts its antihyperglycemic effect in the presence of insulin. Therefore, it should not be used for type 1 diabetes or for the treatment of diabetic ketoacidosis. In the case of combined antidiabetic therapy and liver dysfunction, pioglitazone should be used with caution. Liver enzymes need to be checked regularly.

Therapeutic Class

Thiazolidinedione group

Storage Conditions

Store at 25° C.

Pharmaceutical Name

The White Horse Pharma