Neocin 10Ointment

Generic

Neomycin Sulfate + Bacitracin Zinc

Indications

This is for the treatment of bacterial infections on the skin. This works well for atopic dermatitis, contact dermatitis, infections, eczematoid dermatitis, neurodermatitis, eczema, and anogenital pruritus. It may also be used as an adjuvant in the treatment of some pyodermas, such as impetigo, during systemic antibiotic therapy.

Pharmacology

Bacitracin inhibits the formation of bacterial cell walls and is effective against numerous gram-positive and gram-negative bacteria (e.g. staphylococci, streptococci, corynebacteria, and Clostridia) (e.g. Neisseria and Haemophilus influenzae). They're frequently encountered in topical formulations as broad-spectrum antibacterial agents in combination.

Neomycin binds to the 30S subunits of the bacterial ribosome, limiting protein synthesis and hence affecting DNA synthesis. It has an antibacterial spectrum similar to gentamicin. It is effective against several gram-negative bacteria and some staphylococci strains.

Dosage & Administration

Ointment: Before use, the area for application should be cleaned gently. Derbis such as pus or crusts should be removed from the affected area. Apply two to three times daily to the affected skin area.

Dusting Powder: Antibiotic powder is a non- sterile dusting powder and used for superficial skin infections. A light dusting of the powder to be applied to the affected skin area upto 4 times daily.

Interaction

Zinc bacitracin: When used with other nephrotoxic drugs, the risk of nephrotoxicity increases. It can enhance the effect of neuromuscular blockers.

 Neomycin Sulfate: Additive effect on nephrotoxicity and neurotoxicity of other aminoglycosides, bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and puromycin. Use powerful diuretics to increase toxicity. It will affect the absorption of other drugs. It can enhance the effect of acarbose. May enhance the effect of non-depolarizing muscle relaxants. It can antagonize the parasympathetic effects of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonate therapy. You can change the INR when given with blood thinners. It can inactivate oral typhoid vaccine.

Contraindications

Hypersensitivity to any of its components.

Side Effects

This preparation is usually well tolerated. In rare cases, allergic reactions may be occurred.

Pregnancy & Lactation

This preparation's safety during pregnancy and lactation has yet to be determined. As a result, it should only be used during pregnancy if the possible benefit outweighs the danger to the fetus.

Precautions & Warnings

Zinc bacitracin: When used with other nephrotoxic drugs, the risk of nephrotoxicity increases. It can enhance the effect of neuromuscular blockers.

 Neomycin Sulfate: Additive effect on nephrotoxicity and neurotoxicity of other aminoglycosides, bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and puromycin. Use powerful diuretics to increase toxicity. It will affect the absorption of other drugs. It can enhance the effect of acarbose. May enhance the effect of non-depolarizing muscle relaxants. It can antagonize the parasympathetic effects of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonate therapy. You can change the INR when given with blood thinners. It can inactivate oral typhoid vaccine.

Therapeutic Class

Ophthalmic and Topical antibacterial products

Storage Conditions

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.

Pharmaceutical Name

Opsonin Pharma Ltd.