NORMALIN (NS) - IV 1000 mlInfusion

Generic

Sodium Chloride

Indications

These intravenous solutions are intended for use as supplies of electrolytes and water for hydration in adults and children. Extracellular fluid replenishment, therapy of metabolic alkalosis in the presence of fluid loss, and mild sodium depletion are all indications for 0.9 percent sodium chloride infusion. The infusion of 0.9 percent sodium chloride is also approved for use as a priming solution in hemodialysis operations, and it can be used to start and stop blood transfusions without hemolyzing red blood cells. Infusions of sodium chloride are also used as pharmaceutic aids and diluents for infusing appropriate medication additions. Consult the prescribing information that comes with the additional medications.

Pharmacology

The most abundant extracellular cation is sodium chloride. It restores sodium ions, which is crucial for electrolyte and fluid balance, osmotic pressure management, and water distribution. It is used as a source of electrolytes and water for hydration, metabolic acidosis treatment, haemodialysis priming solution, and hyperosmolar diabetic treatment. It's also utilized as a diluent for infusing medicinal additives that are compatible with it.

Dosage & Administration

This solution is for intravenous use only. Dosage is to be directed by a physician and is dependent upon age, weight, clinical condition of the patient and laboratory determinations. Frequent laboratory determinations and clinical evaluation are essential to monitor changes in blood glucose and electrolyte concentrations, and fluid and electrolyte balance during prolonged parenteral therapy.

In the average adult, daily requirements of sodium and chloride are met by the infusion of one liter of 0.9% sodium chloride (154 mEq each of sodium and chloride). There is no specific pediatric dose. The dose is dependent on weight, clinical condition and laboratory results. Follow recommendations of appropriate pediatric reference text. Fluid administration should be based on calculated maintenance or replacement fluid requirements for each patient. 0.9% Sodium Chloride Injection may also be administered intravascularly as a priming fluid in hemodialysis procedures.

Contraindications

This solution is contraindicated where the administration of sodium or chloride could be clinically detrimental.

Side Effects

Fever, infection at the injection site, venous thrombosis or phlebitis extending from the injection site, extravasation, and hypervolemia are all reactions that might occur as a result of the solution or the delivery strategy. The doctor should also be aware of the likelihood of medicine additives causing unpleasant reactions. It's a good idea to look up the prescribing information for any medicine additives that will be used in this way. Symptoms may arise as a result of an excess or deficit of one or more of the ions present in the solution; consequently, electrolyte levels must be monitored often. Hypernatremia has been linked to edema and a worsening of congestive heart failure.

Pregnancy & Lactation

Pregnancy Classification C. Sodium Chloride Injection has not been used in animal reproduction studies. It's also unclear whether Sodium Chloride Injection can harm a fetus or affect reproduction capacity when given to a pregnant woman. Only provide Sodium Chloride Injection to a pregnant lady if it is absolutely necessary.

Mothers who are breastfeeding: This medication is not known to be excreted in human milk. Because many medicines are excreted in human milk, when Sodium Chloride Injection USP is given to a breastfeeding woman, caution should be observed.

Precautions & Warnings

Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation. Significant deviations from normal concentrations may require tailoring of the electrolyte pattern, in these or alternative solutions. This solution should be used with care in patients with hypervolemia, renal insufficiency, urinary tract obstruction, or impending or frank cardiac decompensation.

Extraordinary electrolyte losses such as may occur during protracted nasogastric suction, vomiting, diarrhea or gastrointestinal fistula drainage may necessitate additional electrolyte supplementation. Additional essential electrolytes, minerals and vitamins should be supplied as needed.

Sodium-containing solutions should be administered with caution to patients receiving corticosteroids or corticotropin, or to other salt retaining patients. Care should be exercised in administering solutions containing sodium to patients with renal or cardiovascular insufficiency, with or without congestive heart failure, particularly if they are postoperative or elderly.

Therapeutic Class

Intravenous fluid preparations

Pharmaceutical Name

Popular Pharmaceuticals Ltd.