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PG 150 Capsule

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PG 150Capsule

Leaflet

Generic

Pregabalin

 

Indications

Pregabalin is shown for: Management of neuropathic torment related with diabetic fringe neuropathy Management of post-herpetic neuralgia Adjunctive treatment for grown-up patients with fractional onset seizures Management of fibromyalgia Neuropathic torment related with spinal line damage.

 

Pharmacology

Pregabalin could be a basic subordinate of the inhibitory neurotransmitter gamma-amino butyric corrosive (GABA). It does not tie specifically to GABAA, GABAB, or benzodiazepine receptor. Pregabalin ties with tall fondness to the alpha-2-delta location (an assistant subunit of voltage-gated calcium channels) in central apprehensive framework tissues. Verbal bioavailability of Pregabalin is ≥90% and is autonomous of dosage. It is dispensed with from the systemic circulation basically by renal excretion as unaltered sedate with a cruel disposal half-life of 6.3 hours in subjects with ordinary renal work.

 

Administration & Dosage

Neuropathic pain associated with diabetic peripheral neuropathy: The maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Post-herpetic neuralgia: The recommended dose of Pregabalin is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 75 mg two times a day, or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability.
Adjunctive therapy for adult patients with partial onset seizures: In general, it is recommended that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day.

Management of Fibromyalgia: The recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Neuropathic pain associated with spinal cord injury: The recommended dose range is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Pregabalin capsules can be taken without regards to meals.

 

Interaction

There are no critical intelligent between Pregabalin with other antiepileptic drugs & verbal prophylactic. Pregabalin may potentiate the impacts of ethanol and lorazepam.

 

Contraindications

Pregabalin is contraindicated in patients with known touchiness to Pregabalin or any of its components.

 

Side Effect

The foremost common side impacts incorporate tipsinesslethargy, dry mouth, edema, obscured vision, weight pick up and unusual considering.

 

Pregnancy & Lactation

Pregnancy category of Pregabalin is C. So it ought to as it were utilized in the event that potential advantage legitimizes the potential dangers to the fetus. Pregabalin may be discharged through the breast drain like other drugs, so it ought to be utilized in nursing ladies as it were in the event that the benefits clearly overweigh the hazard.

 

Precautions & Warnings

Cessation of Pregabalin without decreasing may create a sleeping disorderqueasinessmigraine and loose bowels. So it ought to be decreased continuously over a least of 1 week instead of ceased suddenly. Creatinine kinase may be raised on the off chance that treated with Pregabalin. It ought to be ceased quickly on the off chance that myopathy is analyzed or suspected or on the off chance that creatinine kinase is hoisted uniquely.

 

Therapeutic Class

Aide anti-epileptic drugs

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

 

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.
 
 

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Prescription is required for this medicine

Disclaimer:The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website/ app.