Pactorin 2.6Retard Tablet

Generic

Nitroglycerin

Indications

Angina pectoris prevention with nitroglycerin is recommended. This form's beginning of action is too slow to be effective in preventing an acute anginal episode.

Pharmacology

Nitroglycerin promotes vascular smooth muscle relaxation, resulting in a vasodilator action on both peripheral arteries and veins. Venous dilation promotes peripheral blood pooling and reduces venous return to the heart, lowering left ventricular end-diastolic pressure (preload), while arterial relaxation lowers systemic vascular resistance and arterial pressure (afterload).

Dosage & Administration

Dosage should always to be adjusted according to the requirement and response obtained by the individual patient and the severity of the anginal pain. For adults, one Nitroglycerin 2.6 mg sustained released tablet or capsule in morning and evening. This should be taken empty stomach.

Interaction

Nitroglycerin widens fringe blood vessels and may increment the antihypertensive properties of vasodilators, calcium enemies, beta-adrenergic blockers. Concomitant utilize of nitrates with tricyclic antidepressants and liquor may cause tall blood weight. Concomitant utilize of nitrates with phosphodiesterase sort 5 (PDE5) inhibitors, such as sildenafil, vardenafil and tadalafil cause drop in blood weight. Ibuprofen diminishes the clearance and upgrades the hemodynamic impacts of nitroglycerin. Nitroglycerin may diminish the pharmacologic impacts of heparin when utilized concomitantly. Nitrates increment the bioavailability of dihydroergotamine.

Contraindications

In patients who have a known allergy to nitroglycerin, other organic nitrates, or nitrites, or to the medicine's excipients, nitroglycerin is contraindicated. Acute myocardial infarction, severe anemia, head trauma, cerebral haemorrhage, or closed angle glaucoma are also contraindications.

Side Effects

Headaches are common at the beginning of treatment, although they normally go away after a few days. If the headache continues, the dosage should be reduced. Tachycardia, postural hypotension, syncope, cyanosis, and methaemoglobinemia are some of the other side symptoms.

Pregnancy & Lactation

Nitroglycerin should not be used during pregnancy or lactation unless your doctor says it's absolutely necessary.

Precautions & Warnings

Nitroglycerin ought to be utilized with caution in patients who are inclined to closed-angle glaucoma. As with other drugs for the treatment of angina pectoris, unexpected cessation of treatment may lead to worsening of indications. When ceasing long term treatment, the measurement ought to be decreased slowly over a few days, and the quiet carefully observed. The utilize of nitroglycerin amid the early days of intense myocardial localized necrosis requires specific consideration to hemodynamic observing and clinical status to dodge the risks of hypotension and tachycardia.

Therapeutic Class

Coronary vasodilators: nitrates.

Storage Conditions

Keep away from light and heat in a cool, dry area. All drugs should be kept out of the reach of youngsters.

Pharmaceutical Name

ACI Limited