Tiz 10Tablet

Indications of Tiz 10

It's used to treat seasonal and perennial allergic rhinitis symptoms. It's also used to treat the cutaneous symptoms of chronic idiopathic urticaria and allergen-induced asthma.

Pharmaceutical Name of Tiz 10

Euro Pharma Ltd.

Pharmacology

Cetirizine Hydrochloride is a strong H1 receptor antagonist with no anticholinergic or antiserotonic properties. It has almost minimal drowsy impact and does not elicit behavioral abnormalities at pharmacologically active dose levels. It lowers the migration of inflammatory cells and the production of mediators associated with the late phase of the allergic reaction by inhibiting the histamine-mediated early phase of the allergic reaction.

Cetirizine 10 mg achieves peak plasma concentrations of 257 mcg/L within one hour of dosing (980 mcg/L in children), according to pharmacokinetics. Food has no effect on the amount of absorption, however it can slow it down significantly. Between thirty and sixty minutes following administration of a 10 mg dosage of Cetirizine, peak blood levels of 0.3 micrograms/ml are obtained. It has a plasma half-life of about 11 hours. From one subject to the next, absorption is highly consistent. It has a renal clearance of 30 mL/min and an excretion half-life of nine hours.

Dosage & Administration

Adults and Children 6 years and older: 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily).

Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily.

Children 6 months to 2 years : 1/2 teaspoonful once daily. The dose in children 12-23 months of age can be increased to a maximum dose as 1/2 teaspoonful every 12 hours.

Interactions of Tiz 10

No clinically significant drug interactions with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and other drugs have been found.

Contraindications

Patients who have a history of allergy to cetirizine or hydroxyzine are contraindicated.

Side Effects of Tiz 10

The most common side effect of cetirizine is drowsiness.

Pregnancy & Lactation

Cetirizine Hydrochloride is classified as a pregnancy category B by the US Food and Drug Administration. However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain cetirizine hydrochloride. When Cetirizine Hydrochloride is given to a breastfeeding woman, caution should be observed.

Precautions & Warnings

When driving an automobile or operating heavy machinery, extreme caution is advised.

Therapeutic Class

Storage Conditions

Generic of Tiz 10